“We are very pleased to be the first company to bring the thousands of clinical stem cell and regenerative medicine researchers a new stem-cell tool for conducting their studies,” said Michael Haider, president and chief executive officer of BioE. “We look forward to providing this community with stem cells that can be expanded without differentiating and prompted to turn into a variety of tissues, and pioneering an exciting new market within the fields of regenerative medicine and drug screening.”
During the past two years, scientists at BioE have successfully differentiated the cloned MLPCs into tissues representative of the three germinal layers, including neural stem cells, nerve cells, liver/pancreas precursors, skeletal muscle, fat cells, bone cells and blood vessels. Each of BioE’s MLPC clonal stem cell lines was derived from a distinct, individual cell and is genetically normal. BioE will provide genetic and cellular characterization of each clonal stem cell line with each research-use license.
“BioE’s studies utilizing its innovative stem cell isolation technology have led to the characterization of unique and interesting clonal stem cell lines,” said David McKenna, M.D., BioE research collaborator from the University of Minnesota. “The potential for this cell type derived from umbilical cord blood seems unlimited, with multiple applications in cellular therapy — including possibilities in cardiac and other organ-specific regenerative medicine; adjunctive therapy in bone marrow transplantation; and gene therapy based treatment modalities.”
Medical Significance
MLPCs directly address a number of current constraints in stem cell and life sciences research, regenerative medicine, tissue engineering and drug screening. Within these market segments, MLPCs will offer a broad spectrum of new investigational opportunities for a wide variety of researchers due to their ability to expand and their well-defined, controllable differentiation capabilities. As a result, these adult-source stem cells may advance stem cell, life science and regenerative medicine research and lower drug developmental costs, while accelerating the discovery process. For example, some current issues MLPCs could impact include:
— According to a 2003 National Institutes of Health publication titled, “Stem Cells and the Future of Regenerative Medicine,” the Committee on the Biological and Biomedical Applications of Stem Cell Research reported that sources of human stem cells that can be cultured in-vitro are perhaps the most critical need of investigators, and most types of adult-source stem cells are difficult to grow in culture, and their potential plasticity has not been clearly established.
— According to some industry estimates, pharmaceutical companies are projected to spend $6 billion by 2007 on current screening paradigms — such as ADME/Tox (absorption, distribution, metabolism, excretion and toxicity) — for testing drug compound interactions within variable and difficult-to-control cell-based biological systems.
“MLPC clones provide a viable alternative to primary bone marrow and cord blood harvests for developing tissue engineering and regeneration protocols,” said Dr. Colin McGuckin, director of the Stem Cell Therapy Program and reader in Stem Cell Biology and Tissue Engineering at Kingston University in London. “We have been working with BioE for two years on a number of projects, and it is one of the few companies developing protocols for the use of umbilical cord blood that accelerate our work towards finding clinical-grade therapies in hematology and tissue engineering research. With these cell lines, researchers should be able to develop repeatable protocols for tissue engineering research and to characterize the cytokine combination necessary for defined tissue generation. Similarly, biomaterials and bioengineering researchers should also benefit from this type of cell line.”
About BioE
BioE is a biotechnology company developing antibody based diagnostic and therapeutic technologies for use across a wide variety of medical specialties to improve patient outcomes and quality of life. Privately owned, the company was founded in 1993 and is headquartered in St. Paul, Minn. For more information about BioE, please visit www.bioe.com or call (800) 350-6466.
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