Thursday, June 9, 2011 at 03:43 PM
By Shari Roan
Los Angeles Times
LOS ANGELES — Autism is not caused by one or two gene defects but probably by hundreds of mutations, many of which arise spontaneously, according to research that examined the genetic underpinnings of the disorder in more than 1,000 families.
The findings were reported in three studies published Wednesday in the journal Neuron.
They cast autism disorders as genetically complex, involving many potential changes that may produce, essentially, different forms of autism.
The affected genes appear to be part of a large network involved in controlling the development of synapses, the critical junctions between nerve cells that allow them to communicate, according to one of the studies.
Although the work will have no immediate value to patients or their families, the insights provide a wealth of targets to pursue in developing treatments for the disorder, scientists said. Understanding the genetic causes of autism spectrum disorders may promote more accurate diagnoses.
“For the first time we’re getting a sense of how many areas of the genome are likely to contribute to autism,” said Dr. Matthew State, associate professor of psychiatry and of genetics at Yale University and the lead investigator of one of the studies.
Autism spectrum disorders are a group of conditions, ranging from severe to mild, characterized by problems with social interactions. Those with autism may exhibit repetitive behaviors and narrow, obsessive interests; some may have low IQs or problems with language development. About one in 110 U.S. children have an autism spectrum disorder, according to the Centers for Disease Control and Prevention.
An estimated 25 percent of autism spectrum disorder cases are linked to inherited gene mutations passed from parent to child. Some of these high-risk genes have been identified. But researchers have been puzzled by the cause of the disorder in families with no history of autism.
One key question is what is causing the spontaneous mutations, said Irva Hertz-Picciotto, an autism researcher at the University of California, Davis, who was not involved in the studies.
Note: We know that answer – it’s the aborted fetal DNA! See all articles on Autism Research.
They have been doing it. FYI https://www.nih.gov/news-events/news-releases/clinical-trial-mrna-universal-influenza-vaccine-candidate-begins
Excellent question, Eva. The flu shots are not re-developed every year and do not go through pre-clinical testing. The only…
From the article “Influenza Shots for 2024-2025 Season, it states “Like last year, none of the approved influenza shots, are…
The chart displays all of the currently approved influenza shots. Not all are trivalent. The viral composition for this year…
My understanding was that all 2024-2025 flu shots are trivalent, but the above chart still shows some quadrivalent.
This isn't clinical, it's religious: The anger of man worketh not the righteousness of God. - James 1:20 Medical providers…
Thank you so much for providing this information to us. Sometimes I cannot get the information from those giving the…
Therese, Prolia was developed using a genetically modified murine (mouse) platform, whose development did not make use of aborted fetal…
What about ethical concerns about the newer osteoporosis medications? Prolia and Evenity? I have been on a couple of the…
Gary, we updated the website with the 2024-2025 information a number of days ago. The short answer - no real…
This coming flu season 2024 -2025 the flu vaccine is safe to take? There are no mRNA or fetal cells?…
Thank you so much for your endless help with this. May you be abundantly rewarded.
Thank you so much for keeping me updated with the latest information. It is greatly appreciated. God bless you all.…
Jim, that is not correct. We look into the process, including the use of modified lab animals and the nature…
Please stand for life and do not get this vaccine. This is horrible that aborted fetal parts are used to…